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- Title
The development of the heart and microcirculation: role of shear stress.
- Authors
Poelmann, Robert E; Gittenberger-de Groot, Adriana C; Hierck, Beerend P
- Abstract
It is evident that hemodynamic factors have a dominant function already during early cardiogenesis. Flow and ensuing shear stress are sensed by endothelial cells by, ciliary modified, cytoskeletal deformation which then activates a number of subcellular structures and molecules. Shear stress dependent changes mostly converge towards NF kappa B signaling and DNA binding, thereby altering metabolic paths and influencing differentiation of the cells. Geometry of the vascular system heavily affects the flow and shear patterns, as is the case in the adult vasculature where atheroprone areas nicely coincide with the frequency of the primary cilium as shear stress sensor.
- Publication
Medical & biological engineering & computing, 2008, Vol 46, Issue 5, p479
- ISSN
0140-0118
- Publication type
Journal Article
- DOI
10.1007/s11517-008-0304-4