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- Title
Regulation of mu opioid receptor expression in developing T cells.
- Authors
Zhang, Lily; Belkowski, Judith Sliker; Briscoe, Tammi; Rogers, Thomas J
- Abstract
We have previously reported that functionally active μ-opioid receptors (MOR) are constitutively expressed at relatively low levels by developing T cells in the thymus. However, very little is known about the regulation of MOR expression by immature T cells. In this report, we first attempted to determine the effect of T cell receptor-induced T cell activation on the expression of MOR. We activated T cells with either the combination of anti-CD3 and CD28, or with superantigen, and observed a substantial increase in MOR transcript expression. We also chose to examine the effect of cytokine-mediated T cell activation on the expression of this opioid receptor. We selected certain cytokines that play a role in T cell development and are known to be present at functional levels in the thymus gland. Our results show that interferon γ (IFNγ), IL-1β, and IL-2, and in particular transforming growth factor-β (TGFβ), all induced significant increases in MOR transcript expression. On the other hand, both TNFα and IL-7 exhibited much weaker effects on MOR expression. These results show that MOR expression by developing T cells is strongly regulated by several cytokines involved in T cell development in the thymus gland.
- Publication
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2012, Vol 7, Issue 4, p835
- ISSN
1557-1904
- Publication type
Journal Article
- DOI
10.1007/s11481-012-9396-6