We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis.
- Authors
Tsunoda, Ikuo; Fujinami, Robert S
- Abstract
Theiler's murine encephalomyelitis virus (TMEV) infection of mice is an experimental model for multiple sclerosis (MS). TMEV induces a biphasic disease in susceptible mouse strains. During the acute phase, 1 week after infection, TMEV causes polioencephalomyelitis characterized by infection and apoptosis of neurons in the gray matter of the brain. During the chronic phase, about 1 month after infection, virus infects glial cells and macrophages, and induces inflammatory demyelination with oligodendrocyte apoptosis and axonal degeneration in the white matter of the spinal cord. Although antibody, CD4(+), and CD8(+) T cell responses against TMEV capsid proteins play important roles in neuropathogenesis, infectious virus with persistence is necessary to induce demyelination; in general, adoptive transfer of antibody or T cells alone did not induce central nervous system (CNS) disease. The TMEV model can be useful for testing new therapeutic strategies specifically as a viral model for MS. Therapies targeting adhesion molecules, axonal degeneration, and immunosuppression can be beneficial for pure autoimmune CNS demyelinating diseases, such as experimental autoimmune encephalomyelitis, but could be detrimental in virus-induced demyelinating diseases, such as progressive multifocal leukoencephalopathy.
- Publication
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2010, Vol 5, Issue 3, p355
- ISSN
1557-1904
- Publication type
Journal Article
- DOI
10.1007/s11481-009-9179-x