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- Title
Curcumin-like diarylpentanoid analogues as melanogenesis inhibitors.
- Authors
Hosoya, Takahiro; Nakata, Asami; Yamasaki, Fumie; Abas, Faridah; Shaari, Khozirah; Lajis, Nordin Hj; Morita, Hiroshi
- Abstract
Anti-melanogenesis screening of 47 synthesized curcumin-like diarylpentanoid analogues was performed to show that some had a potent inhibitory effect on the melanogenesis in B16 melanoma cells. Their actions were considered to be mostly due to tyrosinase inhibition, tyrosinase expression inhibition, and melanin pigment degradation. The structure-activity relationships of those curcumin-like diarylpentanoid analogues which inhibited the melanogenesis and tyrosinase activity were also discussed. Of those compounds assayed, (2E,6E)-2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone showed the most potent anti-melanogenesis effect, the mechanism of which is considered to be the degradation of the melanin pigment in B16 melanoma cells, affecting neither the tyrosinase activity nor tyrosinase expression.
- Publication
Journal of natural medicines, 2012, Vol 66, Issue 1, p166
- ISSN
1861-0293
- Publication type
Journal Article
- DOI
10.1007/s11418-011-0568-0