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- Title
Specific chemotaxis of magnetically labeled mesenchymal stem cells: implications for MRI of glioma.
- Authors
Bennewitz, Margaret F; Tang, Kevin S; Markakis, Eleni A; Shapiro, Erik M
- Abstract
Glioblastoma multiforme (GBM) is a lethal disease marked by infiltration of cancerous cells into the surrounding normal brain. The dire outcome of GBM patients stems in part from the limitations of current neuroimaging methods. Notably, early cancer detection methodologies are lacking, without the ability to identify aggressive, metastatic tumor cells. We propose a novel approach for tumor detection using magnetic resonance imaging (MRI) based on imaging specific tumor tropism of mesenchymal stem cells (MSCs) labeled with micron-sized iron oxide particles (MPIOs).
- Publication
Molecular imaging and biology, 2012, Vol 14, Issue 6, p676
- ISSN
1860-2002
- Publication type
Journal Article
- DOI
10.1007/s11307-012-0553-3