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- Title
Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques.
- Authors
Razansky, Daniel; Harlaar, Niels J; Hillebrands, Jan Luuk; Taruttis, Adrian; Herzog, Eva; Zeebregts, Clark J; van Dam, Gooitzen M; Ntziachristos, Vasilis
- Abstract
Elevated expression of cathepsins, integrins and matrix metalloproteinases (MMPs) is typically associated with atherosclerotic plaque instability. While fluorescent tagging of such molecules has been amply demonstrated, no imaging method was so far shown capable of resolving these inflammation-associated tags with high fidelity and resolution beyond microscopic depths. This study is aimed at demonstrating a new method with high potential for noninvasive clinical cardiovascular diagnostics of vulnerable plaques using high-resolution deep-tissue multispectral optoacoustic tomography (MSOT) technology.
- Publication
Molecular imaging and biology, 2012, Vol 14, Issue 3, p277
- ISSN
1860-2002
- Publication type
Journal Article
- DOI
10.1007/s11307-011-0502-6