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- Title
Saposin C coupled lipid nanovesicles enable cancer-selective optical and magnetic resonance imaging.
- Authors
Kaimal, Vinod; Chu, Zhengtao; Mahller, Yonatan Y; Papahadjopoulos-Sternberg, Brigitte; Cripe, Timothy P; Holland, Scott K; Qi, Xiaoyang
- Abstract
Nanovesicles composed of the phospholipid dioleylphosphatidylserine (DOPS) and a fusogenic protein, saposin C (SapC), selectively target and induce apoptotic cell death in a variety of human cancer cells in vitro and in vivo. We tested whether such tumor-homing nanovesicles are capable of delivering fluorescent probes and magnetic resonance (MR) contrast agents to cancerous tissue to aid in earlier detection and improve visualization.
- Publication
Molecular imaging and biology, 2011, Vol 13, Issue 5, p886
- ISSN
1860-2002
- Publication type
Journal Article
- DOI
10.1007/s11307-010-0417-7