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- Title
Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes.
- Authors
Singhal, Tarun; Ding, Yu-Shin; Weinzimmer, David; Normandin, Marc D; Labaree, David; Ropchan, Jim; Nabulsi, Nabeel; Lin, Shu-fei; Skaddan, Marc B; Soeller, Walter C; Huang, Yiyun; Carson, Richard E; Treadway, Judith L; Cline, Gary W
- Abstract
The aim of this study is to compare the utility of two positron emission tomography (PET) imaging ligands ((+)-[(11)C]dihydrotetrabenazine ([(11)C]DTBZ) and the fluoropropyl analog ([(18)F]FP-(+)-DTBZ)) that target islet β-cell vesicular monoamine transporter type II to measure pancreatic β-cell mass (BCM).
- Publication
Molecular imaging and biology, 2011, Vol 13, Issue 5, p973
- ISSN
1860-2002
- Publication type
Journal Article
- DOI
10.1007/s11307-010-0406-x