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- Title
Biodistribution and clearance of small molecule hapten chelates for pretargeted radioimmunotherapy.
- Authors
Orcutt, Kelly Davis; Nasr, Khaled A; Whitehead, David G; Frangioni, John V; Wittrup, K Dane
- Abstract
The favorable pharmacokinetics and clinical safety profile of metal-chelated 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) suggests that it might be an ideal hapten for pretargeted radioimmunotherapy. In an effort to minimize hapten retention in normal tissues and determine the effect of various chemical adducts on in vivo properties, a series of DOTA-based derivatives were evaluated.
- Publication
Molecular imaging and biology, 2011, Vol 13, Issue 2, p215
- ISSN
1860-2002
- Publication type
Journal Article
- DOI
10.1007/s11307-010-0353-6