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- Title
Bioproduction of prostaglandins in a transgenic liverwort, Marchantia polymorpha.
- Authors
Takemura, Miho; Kanamoto, Hirosuke; Nagaya, Shingo; Ohyama, Kanji
- Abstract
Prostaglandins are biologically active substances used in a wide range of medical treatments. Prostaglandins have been supplied mainly by chemical synthesis; nevertheless, the high cost of prostaglandin production remains a factor. To lower the cost of prostaglandin production, we attempted to produce prostaglandins using a liverwort, Marchantia polymorpha L., which accumulates arachidonic acid, which is known as a substrate of prostaglandins. Here we report the first bioproduction of prostaglandins in plant species by introducing a cyclooxygenase gene from a red alga, Gracilaria vermiculophylla into the liverwort. The transgenic liverworts accumulated prostaglandin F2α, prostaglandin E2 and prostaglandin D2 which were not detected in the wild-type liverwort. Moreover, we succeeded in drastically increasing the bioproduction of prostaglandins using an in vitro reaction system with the extracts of transgenic liverworts.
- Publication
Transgenic research, 2013, Vol 22, Issue 5, p905
- ISSN
1573-9368
- Publication type
Journal Article
- DOI
10.1007/s11248-013-9699-2