We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypolipidemic and antioxidative effects of noni (Morinda citrifolia L.) juice on high- fat/cholesterol-dietary hamsters.
- Authors
Lin, Yi-Ling; Chou, Chung-Hsi; Yang, Deng-Jye; Chen, Jr-Wei; Tzang, Bor-Show; Chen, Yi-Chen
- Abstract
Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ&#95;L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ&#95;M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ&#95;H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet.
- Publication
Plant foods for human nutrition (Dordrecht, Netherlands), 2012, Vol 67, Issue 3, p294
- ISSN
1573-9104
- Publication type
Journal Article
- DOI
10.1007/s11130-012-0309-x