Works matching DE "PROTEOLYSIS"

Results: 5000

De novo designed protein guiding targeted protein degradation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-62050-z

By:

Li, Zhendong;
Qiao, Gan;
Wang, Xianghe;
Wang, Ming;
Cheng, Jinyu;
Hu, Guipeng;
Li, Xiaomin;
Wu, Jing;
Liu, Jia;
Gao, Cong;
Liu, Liming

Publication type:

Article

АЛМАТЫ ОБЛЫСЫНЫҢ ЕКІ ЫСТЫҚ БҰЛАҚ КӨЗІНДЕГІ КЕРАТИНАЗАЛЫҚ БЕЛСЕНДІЛІГІ БАР ТЕРМОФИЛЬДІ БАКТЕРИЯЛАРДЫҢ СИПАТТАМАСЫ.

Published in:

Experimental Biology (1563-0218), 2025, v. 102, n. 1, p. 128, doi. 10.26577/bb2025102111

By:

Бисенова, Ұ. М.;
Кистаубаева, А. С.;
Абдулжанова, М. А.

Publication type:

Article

Nrf2/UBE3B protects against acute lung injury by inhibiting ferritinophagy through the ubiquitination of NCOA4.

Published in:

Biology Direct, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13062-025-00678-z

By:

Gu, Yunfan;
Dong, Hui;
Wang, Yanjun;
Hu, Beibei;
Jiang, Hong;
Hu, Rong

Publication type:

Article

Role of laccase and xylanase, with or without ferulic acid esterase-producing Lactiplantibacillus plantarum, on the aerobic stability, microbial composition and in vitro degradability of mulberry silage.

Published in:

BMC Microbiology, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12866-025-04165-3

By:

Su, Ya;
Yu, Qiang;
Xi, Yulong;
Rong, Yuanjiang;
Long, Yixi;
Xie, Yixiao;
Sun, Hong;
Hao, Jun;
Yang, Fuyu;
Zheng, Yulong

Publication type:

Article

Effects Of Carbaryl Exposure On The Protein Content Of Cyprinus Carpio.

Published in:

Cuestiones de Fisioterapia, 2025, v. 54, n. 4, p. 5545

By:

Arumugam, M.;
Prabakaran, Victor

Publication type:

Article

Mechanistic insights into PROTAC-mediated degradation through an integrated framework of molecular dynamics, free energy landscapes, and quantum mechanics: A case study on kinase degraders.

Published in:

Journal of Computer-Aided Molecular Design, 2025, v. 39, n. 1, p. 1, doi. 10.1007/s10822-025-00630-3

By:

Nandy, Ashis;
Boppana, Kiran;
Phukan, Samiron

Publication type:

Article

Identification of host cell surface proteins inhibiting furin dependent proteolytic processing of viral glycoproteins.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-11164-x

By:

Williams, Nathalia;
Chabert, Mehdi;
Besomi, Alicia;
Silva, Filo;
Sobiech, Karolina;
Schmolke, Mirco

Publication type:

Article

Methods to accelerate PROTAC drug discovery.

Published in:

Biochemical Journal, 2025, v. 482, n. 13, p. 921, doi. 10.1042/BCJ20243018

By:

Osman, Jeyan;
Thompson, Philip E.;
Jörg, Manuela;
Scanlon, Martin J.

Publication type:

Article

Developing a Functional Triticale Noodle by Incorporating Silkworm (Antheraea pernyi and Bombyx mori) Pupae.

Published in:

Foods, 2025, v. 14, n. 13, p. 2282, doi. 10.3390/foods14132282

By:

Liu, Yu;
Liu, Ruixin;
Phuseerit, Onanong;
Li, Hua;
Siriamornpun, Sirithon

Publication type:

Article

The Potential of Combining Faba Bean (Vicia faba L.) and Pea Pod (Pisum sativum L.) Flours to Enhance the Nutritional Qualities of Food Products.

Published in:

Foods, 2025, v. 14, n. 13, p. 2167, doi. 10.3390/foods14132167

By:

Ben Said, Khaoula;
Hedhili, Amel;
Bellagha, Sihem;
Gliguem, Hela;
Dufrechou, Marie

Publication type:

Article

The Identification of Proteolytic Substrates of Calpain-5 with N-Terminomics.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6459, doi. 10.3390/ijms26136459

By:

Gal, Jozsef;
Dufour, Antoine;
Young, Daniel;
Yang, Eddy S.;
Geddes, James W.

Publication type:

Article

Effectiveness of PROTAC BET Degraders in Combating Cisplatin Resistance in Head and Neck Cancer Cells.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6185, doi. 10.3390/ijms26136185

By:

Luffman, Natalie;
Ahmadinejad, Fereshteh;
Finnegan, Ryan M.;
Raymond, Marissa;
Gewirtz, David A.;
Harada, Hisashi

Publication type:

Article

Effects of Polypropylene and Polyethylene Terephthalate Microplastics on Trypsin Structure and Function.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 5974, doi. 10.3390/ijms26135974

By:

Lujic, Tamara;
Gligorijevic, Nikola;
Stanic-Vucinic, Dragana;
Krstic Ristivojevic, Maja;
Mutic, Tamara;
Wimmer, Lukas;
Dailey, Lea Ann;
Cirkovic Velickovic, Tanja

Publication type:

Article

Pembrolizumab promotes degradation of cyclin dependent kinase 6 and suppresses ovarian cancer progression in vitro.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-11043-5

By:

Wu, Yi;
Xu, Ziyan;
Kou, Zuqiang;
Ye, Qiuling;
Chen, Liting;
Gou, Boyu

Publication type:

Article

The Role of Protein Ubiquitination in the Onset and Progression of Sepsis.

Published in:

Cells (2073-4409), 2025, v. 14, n. 13, p. 1012, doi. 10.3390/cells14131012

By:

Chen, Meng-Yan;
Liu, Yang;
Fang, Min

Publication type:

Article

"Unraveling EMILIN-1: A Multifunctional ECM Protein with Tumor-Suppressive Roles" Mechanistic Insights into Cancer Protection Through Signaling Modulation and Lymphangiogenesis Control.

Published in:

Cells (2073-4409), 2025, v. 14, n. 13, p. 946, doi. 10.3390/cells14130946

By:

Muzzin, Samanta;
Timis, Enrica;
Doliana, Roberto;
Mongiat, Maurizio;
Spessotto, Paola

Publication type:

Article

The Ac/N-Degron Domain of MARCHF6 E3 Ubiquitin Ligase and Its Role in Regulating Ferroptosis.

Published in:

Cells (2073-4409), 2025, v. 14, n. 13, p. 954, doi. 10.3390/cells14130954

By:

Omoniyi, Hope;
Hohman, Grace;
Eldeeb, Mohamed

Publication type:

Article

Multi-path direct current spinal stimulation extended survival in the SOD1-G93A model of amyotrophic lateral sclerosis.

Published in:

Frontiers in Neurology, 2025, p. 1, doi. 10.3389/fneur.2025.1594169

By:

Ahmed, Zaghloul;
Samaddar, Sreyashi;
Hassieb, May;
Sadek, Rodina;
Morozova, Viktoriya;
Begum, Sultana

Publication type:

Article

Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1.

Published in:

PLoS Genetics, 2025, v. 21, n. 7, p. 1, doi. 10.1371/journal.pgen.1011794

By:

Zhang, Chenliang;
Wu, Quanyou;
Zhang, Huan;
Liu, RuiChen;
Li, Liping

Publication type:

Article

Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.

Published in:

Frontiers in Physiology, 2025, p. 1, doi. 10.3389/fphys.2025.1607873

By:

Yang, Jingyi;
Wang, Yingdong;
Xu, Yuzhe;
Jia, Xinqi;
Lu, Fangping

Publication type:

Article

Integrative Multi-Omics Analysis and Experimental Validation Identify SPOP as a Prognostic Biomarker and Immune Regulator in Lung Adenocarcinoma.

Published in:

Journal of Cancer, 2025, v. 16, n. 9, p. 2984, doi. 10.7150/jca.111751

By:

Yu Wang;
Tao Jiang;
Ziyou Lin;
Peijun Dai;
Wenxin Wei;
Chengyuan Dong;
Xuelin Zhang;
Zhifeng Zhang

Publication type:

Article

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 34, p. 1, doi. 10.1002/chem.202404218

By:

Pierri, Martina;
Bove, Guglielmo;
Gazzillo, Erica;
Colarusso, Ester;
Scala, Francesca;
Pepe, Giacomo;
Terracciano, Stefania;
Chini, Maria Giovanna;
Simonelli, Nicla;
Bruno, Ines;
Nebbioso, Angela;
Campiglia, Pietro;
Bifulco, Giuseppe;
Altucci, Lucia;
Del Gaudio, Nunzio;
Lauro, Gianluigi

Publication type:

Article

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology.

Published in:

Angewandte Chemie, 2025, v. 137, n. 28, p. 1, doi. 10.1002/ange.202503958

By:

Baker, Andrew G.;
Ho, Adrian Pui Ting;
Itzhaki, Laura S.;
Fruk, Ljiljana

Publication type:

Article

Nutrients, Bioactive Compounds, and Antioxidant Activities of Garden Cress (Lepidium sativum L.) Seeds and Their Applications in Food Technology and Therapeutic Nutrition.

Published in:

Alexandria Science Exchange Journal, 2025, v. 46, n. 2, p. 263, doi. 10.21608/asejaiqjsae.2025.423922

By:

Ibrahim, Marwa E.;
Elhassaneen, Yousif A.;
Abd El-Aziz, Amany A.

Publication type:

Article

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.106844

By:

Han Zhou;
Tonglian Zhou;
Wenli Yu;
Liping Liu;
Yeonjin Ko;
Johnson, Kristen A.;
Wilson, Ian A.;
Schultz, Peter G.;
Bollong, Michael J.

Publication type:

Article

Sensl: a synthetic biology sensor for tracking strigolactone signaling in rice.

Published in:

New Phytologist, 2025, v. 247, n. 3, p. 1031, doi. 10.1111/nph.70242

By:

Li, Yirou;
Wang, Fei;
Du, Ran;
Xie, Daoxin;
Yan, Jianbin;
Shan, Xiaoyi

Publication type:

Article

SE(3)-equivariant ternary complex prediction towards target protein degradation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61272-5

By:

Xue, Fanglei;
Zhang, Meihan;
Li, Shuqi;
Gao, Xinyu;
Wohlschlegel, James A.;
Huang, Wenbing;
Yang, Yi;
Deng, Weixian

Publication type:

Article

In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61175-5

By:

Hu, Xiaoqian;
Yao, Qingxin;
Wu, Xiaobo;
Chen, Jiali;
Zhang, Ruijia;
Zhao, Yan;
Gao, Yuan

Publication type:

Article

Structural insights into the human HRD1 ubiquitin ligase complex.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61143-z

By:

Guo, Liling;
Liu, Guoyun;
He, Jingjing;
Jia, Xiaoxiao;
He, Yonglin;
Wang, Zhenhua;
Qian, Hongwu

Publication type:

Article

Effect of dry ice addition and wilting on the rates of fermentation and proteolysis in ensiled alfalfa.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-05884-3

By:

Borsuk-Stanulewicz, Marta;
Białobrzewski, Ireneusz;
Przemieniecki, Sebastian Wojciech;
Purwin, Cezary

Publication type:

Article

Local Ancestry and Selection in the Genomes of Russian Black Pied Cattle.

Published in:

Sci (2413-4155), 2025, v. 7, n. 2, p. 51, doi. 10.3390/sci7020051

By:

Igoshin, Alexander V.;
Yurchenko, Andrey A.;
Yudin, Nikolay S.;
Larkin, Denis M.

Publication type:

Article

E3 ubiquitin ligase Smurf1 promotes cardiomyocyte pyroptosis by mediating ubiquitin-dependent degradation of TRIB2 in a rat model of heart failure.

Published in:

International Reviews of Immunology, 2025, v. 44, n. 4, p. 165, doi. 10.1080/08830185.2024.2434058

By:

Liu, Wei;
Cai, Xin;
Duan, Shiying;
Shen, Jihua;
Wu, Jiayuan;
Zhou, Zhengwei;
Yu, Kaili;
He, Caihong;
Wang, Yuqin

Publication type:

Article

Incorporation of egg white powder into the heat-induced gel from Peruvian hake (Merluccius gayi peruanus) surimi to improve gel properties.

Published in:

Fisheries Science, 2025, v. 91, n. 4, p. 845, doi. 10.1007/s12562-025-01883-5

By:

Shi, Yafang;
Geng, Jie-Ting;
Yang, Chenxu;
Guo, Zulin;
Yoshida, Yuichi;
Osako, Kazufumi

Publication type:

Article

Integrated transcriptome and metabolome analyses unraveled critical roles of small intestine during the weaning period of Vespertilio sinensis.

Published in:

BMC Genomics, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12864-025-11784-7

By:

Li, Zixuan;
Guo, Wei;
Chu, Yujia;
Tan, Xiao;
Wang, Hui;
Feng, Jiang;
Liu, Tong

Publication type:

Article

Physiological and morphological impact of physical activity and nutritional interventions to offset disuse-induced skeletal muscle atrophy.

Published in:

European Journal of Translational Myology, 2025, v. 35, n. 2, p. 1, doi. 10.4081/ejtm.2025.13177

By:

Arif, Irfan;
Rasheed, Ayesha;
Nazeer, Sadia;
Shahid, Fareeha

Publication type:

Article

De Novo Design of Structure‐Tunable Multivalent Targeting Chimeras for Tumor‐Targeted PD‐L1 Degradation and Potentiated Cancer Immunotherapy.

Published in:

Angewandte Chemie, 2025, v. 137, n. 27, p. 1, doi. 10.1002/ange.202504233

By:

Zhou, Huiling;
Hou, Bo;
Shan, Yiming;
Huang, Lujia;
Chen, Fangmin;
Ren, Siyuan;
Zhang, Shunan;
Pan, Jiaxing;
Dang, Yijing;
Yu, Haijun;
Xu, Zhiai

Publication type:

Article

The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates.

Published in:

Microorganisms, 2025, v. 13, n. 6, p. 1401, doi. 10.3390/microorganisms13061401

By:

Hameed, H. M. Adnan;
Fang, Cuiting;
Liu, Zhiyong;
Gao, Yamin;
Wang, Shuai;
Chen, Xinwen;
Zhong, Nanshan;
Aung, Htin Lin;
Hu, Jinxing;
Zhang, Tianyu

Publication type:

Article

Dr. Morley Donald Hollenberg. An extraordinary scientist, teacher and mentor.

Published in:

2025

By:

Oikonomopoulou, Katerina;
Diamandis, Eleftherios P.

Publication type:

Letter

Metformin Alleviates Fibrosis of Trabecular Meshwork Cells Induced by TGFβ2 Through the Activation of Autophagy.

Published in:

Dose-Response, 2025, v. 23, n. 2, p. 1, doi. 10.1177/15593258251341598

By:

Ren, Jing;
Wu, Pengtao;
Liu, Mengli;
Zhang, Xuan;
Guo, Zilu;
Liu, Yihan;
Zhao, Rumeng;
Wang, Gang;
Duan, Shichao;
Li, Haijun

Publication type:

Article

Toxicological Responses of Juvenile Gilthead Seabream to Enniatin B and Fumonisin B1.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5676, doi. 10.3390/ijms26125676

By:

Mello, Flávia V.;
Pereira, Cheila;
Özkan, Busenur;
Maulvault, Ana Luísa;
Soares, Florbela;
Pousão-Ferreira, Pedro;
Fernandes, José O.;
Cunha, Sara C.;
Marques, António;
Anacleto, Patrícia

Publication type:

Article

Emerging Concepts of Targeted Protein Degrader Technologies via Lysosomal Pathways.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5582, doi. 10.3390/ijms26125582

By:

Alam, Mohammad Maqusood;
Wasim, Sobia;
Lee, Sang-Yoon

Publication type:

Article

Crystal structure analysis of oxygen‐induced degradation occurring in rsCherry.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2025, v. 81, n. 7, p. 311, doi. 10.1107/S2053230X25005485

By:

Bui, Thi Yen Hang;
Pecqueur, Ludovic;
Dedecker, Peter;
Van Meervelt, Luc

Publication type:

Article

Tissue-Specific Fluorescent Protein Turnover in Free-Moving Flies.

Published in:

Insects (2075-4450), 2025, v. 16, n. 6, p. 583, doi. 10.3390/insects16060583

By:

Bell, Katherine S.;
Ko, Sebastian;
Ali, Sam;
Bognar, Brett;
Khmelkov, Michael;
Rau, Nick;
Peng, Oscar K.;
Eyuboglu, Mavi;
Paine, John;
Tong, Andy;
Saria, Anuj;
Agrawal, Siddharth;
Davies, Kelvin J. A.;
Tower, John

Publication type:

Article

Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-00931-8

By:

Marei, Hany E.;
Bedair, Khaled;
Hasan, Anwarul;
Al-Mansoori, Layla;
Gaiba, Alice;
Morrione, Andrea;
Cenciarelli, Carlo;
Giordano, Antonio

Publication type:

Article

DNA Tweezers with Replaceable Clamps for the Targeted Degradation of Cell Membrane Proteins.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 785, doi. 10.3390/pharmaceutics17060785

By:

Sun, Yang;
Huang, Yichen;
Chen, Daiquan;
Hu, Shangjiu;
Pan, Tao;
Liu, Yuanding;
Wang, Ruowen;
Tan, Weihong

Publication type:

Article

An Alternative Mechanism of Glutamate Dehydrogenase Inhibition by EGCG: Promotion of Protein Degradation.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 877, doi. 10.3390/ph18060877

By:

Zeng, Ziying;
Lin, Chenshui;
Pan, Chuqiao;
Chen, Zhao;
Ruan, Benfang Helen

Publication type:

Article

Antimicrobials: Persisters come under fire.

Published in:

Nature Reviews Microbiology, 2014, v. 12, n. 1, p. 3, doi. 10.1038/nrmicro3181

By:

Kåhrström, Christina Tobin

Publication type:

Article

Proteasomes and protein conjugation across domains of life.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 2, p. 100, doi. 10.1038/nrmicro2696

By:

Maupin-Furlow, Julie

Publication type:

Article

Regulated proteolysis in Gram-negative bacteria - how and when?

Published in:

Nature Reviews Microbiology, 2011, v. 9, n. 12, p. 839, doi. 10.1038/nrmicro2669

By:

Gur, Eyal;
Biran, Dvora;
Ron, Eliora Z.

Publication type:

Article

A Bacteriophage Tailspike Domain Promotes Self-Cleavage of a Human Membrane-Bound Transcription Factor, the Myelin Regulatory Factor MYRF.

Published in:

PLoS Biology, 2013, v. 11, n. 8, p. 1, doi. 10.1371/journal.pbio.1001624

By:

Li, Zhihua;
Park, Yungki;
Marcotte, Edward M.

Publication type:

Article