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- Title
Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin.
- Authors
Jonassen, Ib; Havelund, Svend; Hoeg-Jensen, Thomas; Steensgaard, Dorte Bjerre; Wahlund, Per-Olof; Ribel, Ulla
- Abstract
Basal insulins with improved kinetic properties can potentially be produced using acylation by fatty acids that enable soluble, high-molecular weight complexes to form post-injection. A series of insulins, acylated at B29 with fatty acids via glutamic acid spacers, were examined to deduce the structural requirements.
- Publication
Pharmaceutical research, 2012, Vol 29, Issue 8, p2104
- ISSN
1573-904X
- Publication type
Journal Article
- DOI
10.1007/s11095-012-0739-z