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- Title
A nebulized gelatin nanoparticle-based CpG formulation is effective in immunotherapy of allergic horses.
- Authors
Klier, John; Fuchs, Sebastian; May, Anna; Schillinger, Ulrike; Plank, Christian; Winter, Gerhard; Coester, Conrad; Gehlen, Heidrun
- Abstract
In the recent years, nanotechnology has boosted the development of potential drug delivery systems and material engineering on nanoscale basis in order to increase drug specificity and reduce side effects. A potential delivery system for immunostimulating agents such as cytosine-phosphate-guanine-oligodeoxynucleotides (CpG-ODN) needs to be developed to maximize the efficacy of immunotherapy against hypersensitivity. In this study, an aerosol formulation of biodegradable, biocompatible and nontoxic gelatin nanoparticle-bound CpG-ODN 2216 was used to treat equine recurrent airway obstruction in a clinical study.
- Publication
Pharmaceutical research, 2012, Vol 29, Issue 6, p1650
- ISSN
1573-904X
- Publication type
Journal Article
- DOI
10.1007/s11095-012-0686-8