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- Title
Physicochemical and biological evaluation of siRNA polyplexes based on PEGylated Poly(amido amine)s.
- Authors
Vader, Pieter; van der Aa, Leonardus J; Engbersen, Johan F J; Storm, Gert; Schiffelers, Raymond M
- Abstract
Use of RNA interference as novel therapeutic strategy is hampered by inefficient delivery of its mediator, siRNA, to target cells. Cationic polymers have been thoroughly investigated for this purpose but often display unfavorable characteristics for systemic administration, such as interactions with serum and/or toxicity.
- Publication
Pharmaceutical research, 2012, Vol 29, Issue 2, p352
- ISSN
1573-904X
- Publication type
Journal Article
- DOI
10.1007/s11095-011-0545-z