We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A novel peptide nanomedicine against acute lung injury: GLP-1 in phospholipid micelles.
- Authors
Lim, Sok Bee; Rubinstein, Israel; Sadikot, Ruxana T; Artwohl, James E; Önyüksel, Hayat
- Abstract
Treatment of acute lung injury (ALI) observed in Gram-negative sepsis represents an unmet medical need due to a high mortality rate and lack of effective treatment. Accordingly, we developed and characterized a novel nanomedicine against ALI. We showed that when human glucagon-like peptide 1(7-36) (GLP-1) self-associated with PEGylated phospholipid micelles (SSM), the resulting GLP1-SSM (hydrodynamic size, ~15 nm) exerted effective anti-inflammatory protection against lipopolysaccharide (LPS)-induced ALI in mice.
- Publication
Pharmaceutical research, 2011, Vol 28, Issue 3, p662
- ISSN
1573-904X
- Publication type
Journal Article
- DOI
10.1007/s11095-010-0322-4