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- Title
Effect of Dietary Polyphenon E and EGCG on Lung Tumorigenesis in A/J Mice.
- Authors
Qi Zhang; Huijing Fu; Jing Pan; Jun He; Ryota, Seto; Hara, Yukihiko; Yian Wang; Lubet, Ronald A.; Ming You
- Abstract
To compare the chemopreventive efficacy of Polyphenon E (Poly E), (−)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B( a)P)-induced lung tumors in A/J mice. Female A/J mice were given a single intraperitoneal injection of B( a)P (100 mg/kg body weight). One week after B( a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives. Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) than as a pure compound. EGCG was ineffective when administered by diet likely due to its instability. Thus, EGCG’s efficacy on mice lung tumorigenesis requires the presence of other tea catechins.
- Publication
Pharmaceutical Research, 2010, Vol 27, Issue 6, p1066
- ISSN
0724-8741
- Publication type
Academic Journal
- DOI
10.1007/s11095-010-0056-3