Title

Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities.

Authors

Karakaya, Abdüllatif; Çevik, Ulviye Acar; Erçetin, Tuğba; Özkay, Yusuf; Kaplancıklı, Zafer Asım

Abstract

In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was reacted with thiosemicarbazide and thiosemicarbazone compound was obtained. In the second step, the thiosemicarbazone compound obtained in the first step was reacted with 2-bromoacetophenone derivative compounds and thiazole derivative compounds were obtained. The structures of the synthesized compounds were confirmed by 13C NMR, 1H NMR and HRMS spectral findings, and the melting point was determined for these compounds. The % inhibition values of the compounds on the enzyme acetylcholinesterase (AChE) and butyrylcholinesterase (BuCHe) were investigated.

Subjects

BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE; THIAZOLE derivatives; MELTING points; THIOSEMICARBAZONES; CHEMICAL synthesis

Publication

Pharmaceutical Chemistry Journal, 2023, Vol 57, Issue 9, p1439

ISSN

0091-150X

Publication type

Academic Journal

DOI

10.1007/s11094-023-03007-8