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- Title
Family history and APOE-4 genetic risk in Alzheimer's disease.
- Authors
Donix, Markus; Small, Gary W; Bookheimer, Susan Y
- Abstract
Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.
- Publication
Neuropsychology review, 2012, Vol 22, Issue 3, p298
- ISSN
1573-6660
- Publication type
Journal Article
- DOI
10.1007/s11065-012-9193-2