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- Title
Neurocognitive effects of methamphetamine: a critical review and meta-analysis.
- Authors
Scott, J Cobb; Woods, Steven Paul; Matt, Georg E; Meyer, Rachel A; Heaton, Robert K; Atkinson, J Hampton; Grant, Igor
- Abstract
This review provides a critical analysis of the central nervous system effects of acute and chronic methamphetamine (MA) use, which is linked to numerous adverse psychosocial, neuropsychiatric, and medical problems. A meta-analysis of the neuropsychological effects of MA abuse/dependence revealed broadly medium effect sizes, showing deficits in episodic memory, executive functions, information processing speed, motor skills, language, and visuoconstructional abilities. The neuropsychological deficits associated with MA abuse/dependence are interpreted with regard to their possible neural mechanisms, most notably MA-associated frontostriatal neurotoxicity. In addition, potential explanatory factors are considered, including demographics (e.g., gender), MA use characteristics (e.g., duration of abstinence), and the influence of common psychiatric (e.g., other substance-related disorders) and neuromedical (e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to the clinical management of persons with MA abuse/dependence.
- Publication
Neuropsychology review, 2007, Vol 17, Issue 3, p275
- ISSN
1040-7308
- Publication type
Journal Article
- DOI
10.1007/s11065-007-9031-0