We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TOMM40 poly-T variants and cerebrospinal fluid amyloid beta levels in the elderly.
- Authors
Pomara, Nunzio; Bruno, Davide; Nierenberg, Jay J; Sidtis, John J; Martiniuk, Frank T; Mehta, Pankaj D; Zetterberg, Henrik; Blennow, Kaj
- Abstract
A variable poly-T polymorphism in the TOMM40 gene, which is in linkage disequilibrium with APOE, was recently implicated with increased risk and earlier onset age for late-onset Alzheimer's disease in APOE ε3 carriers. To elucidate potential neurobiological mechanisms underlying this association, we compared the effect of TOMM40 poly-T variants to the effect of APOE, an established LOAD-risk modulator, on cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau levels, in cognitively intact elderly subjects. APOE ε4 carriers showed significant reductions in Aβ 1-42 levels compared to non-ε4 carriers, but no differences were detected across TOMM40 variants. Neither Aβ 1-40 nor tau levels were affected by APOE or TOMM40.
- Publication
Neurochemical research, 2011, Vol 36, Issue 6, p1124
- ISSN
1573-6903
- Publication type
Journal Article
- DOI
10.1007/s11064-011-0459-5