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- Title
High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer.
- Authors
Clarke, Jennifer L; Pao, William; Wu, Nian; Miller, Vincent A; Lassman, Andrew B
- Abstract
Leptomeningeal metastases (LM) occur in 5-10% of patients with solid tumors and are associated with a dismal prognosis. We describe LM from lung adenocarcinoma harboring a mutation in the epidermal growth factor receptor (EGFR) gene that confers sensitivity to the EGFR tyrosine kinase inhibitors (EGFR-TKIs) erlotinib and gefitinib. The CSF concentration of EGFR-TKIs achieved by standard daily dosing may be insufficient for therapeutic effect. However, intermittent (pulsatile) high dose administration (1000-1500 mg/week) achieves a higher CSF concentration than standard dosing, and successfully controlled LM in this patient.
- Publication
Journal of neuro-oncology, 2010, Vol 99, Issue 2, p283
- ISSN
1573-7373
- Publication type
Journal Article
- DOI
10.1007/s11060-010-0128-6