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- Title
The application of super paramagnetic iron oxide-labeled mesenchymal stem cells in cell-based therapy.
- Authors
Qi, Yiying; Feng, Gang; Huang, Zhongming; Yan, Weiqi
- Abstract
Mesenchymal stem cell (MSC)-based therapy has great potential for tissue regeneration. However, being able to monitor the in vivo behavior of implanted MSCs and understand the fate of these cells is necessary for further development of successful therapies and requires an effective, non-invasive and non-toxic technique for cell tracking. Super paramagnetic iron oxide (SPIO) is an idea label and tracer of MSCs. MRI can be used to follow SPIO-labeled MSCs and has been proposed as a gold standard for monitoring the in vivo biodistribution and migration of implanted SPIO-labeled MSCs. This review discusses the biological effects of SPIO labeling on MSCs and the therapeutic applications of local or systemic delivery of these labeled cells.
- Publication
Molecular biology reports, 2013, Vol 40, Issue 3, p2733
- ISSN
1573-4978
- Publication type
Journal Article
- DOI
10.1007/s11033-012-2364-7