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- Title
Analysis of the polymorphisms in the caprine Gli3 gene and their associations with production traits in goats.
- Authors
Jin, Q J; Chen, D X; Yang, L; Fang, X T; Zhang, C L; Lei, C Z; Chen, H
- Abstract
Gli3 is a zinc finger transcription factor which plays a critical role in regulating animal development, metabolism and energy partitioning and thus has the potential to influence economical important traits in farm animals. In this study, we screened the complete exons of the caprine Gli3 gene using PCR-SSCP methods in 430 individuals from three goat breeds to identify sequence variants that might be associated with growth traits. Six novel mutations (GU363952:g.739C>G, 749A>T, 1636C>A, 1982delT, 1983T>C, 2856T>C) were identified. Significant associations were observed between the mutations GU363952:g.739C>G and g.749A>T with body height, chest circumference and canon circumference. Individuals with genotype G4-CC/AA and G4-CG/AT were significantly higher than individuals with genotype G4-GG/TT in body height, chest circumference and canon circumference. The results of this study suggested that the Gli3-gene-specific SNP could be a useful marker for growth traits in future marker-assisted selection programs in goat.
- Publication
Molecular biology reports, 2013, Vol 40, Issue 2, p1911
- ISSN
1573-4978
- Publication type
Journal Article
- DOI
10.1007/s11033-012-2247-y