We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis.
- Authors
Wang, Jing-Jun; Zheng, Yuan; Sun, Liang; Wang, Li; Yu, Peng-Bo; Dong, Jian-Hua; Zhang, Lei; Xu, Jing; Shi, Wei; Ren, Yu-Chun
- Abstract
Colorectal cancer constitutes a significant proportion of the global burden of cancer morbidity and mortality. A number of studies have been conducted to explore whether TP53 codon 72 polymorphism is associated with colorectal cancer susceptibility. However, controversial results were obtained. In order to derive a more precise estimation of the relationship, we systematically searched Medline, Google scholar, and Ovid database for studies reported before May 2010. A total of 3603 colorectal cancer cases and 5524 controls were included. TP53 codon 72 polymorphism was not associated with colorectal cancer risk in all genetic models (for dominant model: OR = 0.99, 95% CI: 0.86-1.15; for recessive model: OR = 1.00, 95% CI: 0.81-1.23; for Arg/Pro vs. Arg/Arg: OR = 1.00, 95% CI: 0.87-1.15; for Pro/Pro vs. Arg/Arg: OR = 0.97, 95% CI: 0.76-1.25). In the subgroup analyses by ethnic groups and sources of controls, no significant associations were found in all models. Taken together, this meta-analysis suggested that the biologically usefulness of TP53 codon 72 polymorphism as a selection marker in colorectal cancer susceptibility may be very limited.
- Publication
Molecular biology reports, 2011, Vol 38, Issue 8, p4847
- ISSN
1573-4978
- Publication type
Journal Article
- DOI
10.1007/s11033-010-0619-8