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- Title
Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people.
- Authors
Zhen Yang; Jie Wen; Xiaoming Tao; Bin Lu; Yanping Du; Mei Wang; Xuanchun Wang; Weiwei Zhang; Wei Gong; Charlotte Ling; Songhua Wu; Renming Hu
- Abstract
Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis I°, 90 with steatosis hepatis II° and 28 with steatosis hepatis III°) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139-2.271, P = 7.2 × 10). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride ( P = 3.8 × 10) and CRP ( P = 2.9 × 10) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia.
- Publication
Molecular Biology Reports, 2011, Vol 38, Issue 2, p1145
- ISSN
0301-4851
- Publication type
Academic Journal
- DOI
10.1007/s11033-010-0212-1