We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The multifaceted roles of autophagy in tumors-implications for breast cancer.
- Authors
Debnath, Jayanta
- Abstract
Autophagy is an evolutionarily conserved lysosomal degradation process that is crucial for adaptation to stress as well as in cellular homeostasis. In cancer, our current understanding has uncovered multifaceted roles for autophagy in tumor initiation and progression. Although genetic evidence corroborates a critical role for autophagy as a tumor suppressor mechanism, autophagy can also promote the survival and fitness of advanced tumors subject to stress, which has important implications during breast cancer progression and metastasis. Here, I discuss the mechanisms and the evidence underlying these diverse roles for autophagy in cancer and speculate on specific circumstances in which autophagy can be most effectively targeted for breast cancer treatment.
- Publication
Journal of mammary gland biology and neoplasia, 2011, Vol 16, Issue 3, p173
- ISSN
1573-7039
- Publication type
Journal Article
- DOI
10.1007/s10911-011-9223-3