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- Title
Post-transplantation B cell function in different molecular types of SCID.
- Authors
Buckley, Rebecca H; Win, Chan M; Moser, Barry K; Parrott, Roberta E; Sajaroff, Elisa; Sarzotti-Kelsoe, Marcella
- Abstract
Severe combined immunodeficiency (SCID) is a syndrome of diverse genetic cause characterized by profound deficiencies of T, B and sometimes NK cell function. Non-ablative HLA-identical or rigorously T cell-depleted haploidentical parental bone marrow transplantation (BMT) results in thymus-dependent genetically donor T cell development in the recipients, leading to a high rate of long-term survival. However, the development of B cell function has been more problematic. We report here results of analyses of B cell function in 125 SCID recipients prior to and long-term after non-ablative BMT, according to their molecular type.
- Publication
Journal of clinical immunology, 2013, Vol 33, Issue 1, p96
- ISSN
1573-2592
- Publication type
Journal Article
- DOI
10.1007/s10875-012-9797-6