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- Title
Alterations in immune function are associated with liver enzyme elevation in HIV and HCV co-infection after commencement of combination antiretroviral therapy.
- Authors
Cameron, Barbara Anne; Emerson, Carol R; Workman, Cassy; Kelly, Mark D; Lloyd, Andrew R; Post, Jeffrey J
- Abstract
The cause of liver enzyme elevation during combination antiretroviral therapy in people with human immunodeficiency virus and hepatitis C virus co-infection is unclear. We followed 12 subjects (five with alanine transaminase elevation) for 24 weeks after combination antiretroviral therapy commencement. Immune responses against hepatitis C virus, human immunodeficiency virus and other viruses were assessed by interferon-γ ELISpot. Plasma cytokines, chemokines and anti-hepatitis C virus antibody levels were measured. Those with liver enzyme elevation had higher ELISpot responses both against hepatitis C virus non-structural regions and other viral antigens, and their anti-hepatitis C virus antibody levels were consistently higher, suggesting that reconstitution of both hepatitis C virus-specific and non-hepatitis C virus-specific immune responses may be associated with liver transaminase elevation during combination antiretroviral therapy.
- Publication
Journal of clinical immunology, 2011, Vol 31, Issue 6, p1079
- ISSN
1573-2592
- Publication type
Journal Article
- DOI
10.1007/s10875-011-9587-6