We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Plasma IL-17A Is Increased in New-Onset SLE Patients and Associated with Disease Activity.
- Authors
Xiao Qi Chen; Yan Cheng Yu; Hao Hua Deng; Jia Zhong Sun; Zhe Dai; Yu Wen Wu; Miao Yang
- Abstract
To investigate the role of interleukin-17A (IL-17A) and Th17 cell in the pathogenesis of systemic lupus erythematosus (SLE), we studied the plasma IL-17A and the expression of Th17 cell transcription factor RORγt in Chinese new-onset SLE patients. Sixty SLE patients aged between 18 and 40 years and 56 age-matched healthy volunteers were involved in the study. Enzyme-linked immunosorbent assay was used to measure plasma IL-17A level, and rea1-time fluorescent quantitative polymerase chain reaction was used to measure RORγt mRNA. The results showed that both IL-17A level and RORγt mRNA in SLE patients were higher than that of controls. Correlation analysis indicated that plasma IL-17A level was positively correlated with Systemic Lupus Erythematosus Disease Activity Index, not with RORγt mRNA. We concluded that IL-17A might play a role in the pathogenesis of SLE and associated with disease activity. RORγt-determined Th17 cell might be involved with increased IL-17A in SLE but not exclusively the unique source.
- Publication
Journal of Clinical Immunology, 2010, Vol 30, Issue 2, p221
- ISSN
0271-9142
- Publication type
Academic Journal
- DOI
10.1007/s10875-009-9365-x