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- Title
Fragment-based drug discovery using NMR spectroscopy.
- Authors
Harner, Mary J; Frank, Andreas O; Fesik, Stephen W
- Abstract
Nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful tool for fragment-based drug discovery over the last two decades. While NMR has been traditionally used to elucidate the three-dimensional structures and dynamics of biomacromolecules and their interactions, it can also be a very valuable tool for the reliable identification of small molecules that bind to proteins and for hit-to-lead optimization. Here, we describe the use of NMR spectroscopy as a method for fragment-based drug discovery and how to most effectively utilize this approach for discovering novel therapeutics based on our experience.
- Publication
Journal of biomolecular NMR, 2013, Vol 56, Issue 2, p65
- ISSN
1573-5001
- Publication type
Journal Article
- DOI
10.1007/s10858-013-9740-z