We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Titanium dioxide (TiO<sub>2</sub>) nanoparticles filled poly( d, l lactid acid) (PDLLA) matrix composites for bone tissue engineering.
- Authors
Gerhardt, L.-C.; Jell, G. M. R.; Boccaccini, A. R.
- Abstract
Titanium dioxide (TiO2) nanoparticles were investigated for bone tissue engineering applications with regard to bioactivity and particle cytotoxicity. Composite films on the basis of poly( d, l lactid acid) (PDLLA) filled with 0, 5 and 30 wt% TiO2 nanoparticles were processed by solvent casting. Bioactivity, characterised by formation of hydroxyapatite (HA) on the materials surface, was investigated for both the free TiO2 nanoparticles and PDLLA/TiO2 composite films upon immersion in supersaturated simulated body fluid (1.5 SBF) for up to 3 weeks. Non-stoichiometric HA nanocrystals (ns-HA) with an average diameter of 40 nm were formed on the high content (30 wt% TiO2) composite films after 2 weeks of immersion in 1.5 SBF. For the pure PDLLA film and the low content composite films (5 wt% TiO2) trace amounts of ns-HA nanocrystals were apparent after 3 weeks. The TiO2 nanopowder alone showed no bioactivity. The effect of TiO2 nanoparticles (0.5–10,000 μg/mL) on MG-63 osteoblast-like cell metabolic activity was assessed by the MTT assay. TiO2 particle concentrations of up to 100 μg/mL had no significant effect on MG-63 cell viability.
- Publication
Journal of Materials Science: Materials in Medicine, 2007, Vol 18, Issue 7, p1287
- ISSN
0957-4530
- Publication type
Academic Journal
- DOI
10.1007/s10856-006-0062-5