Title: Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder.
Authors: Casey, S.; Carter, M.; Looney, A. M.; Livingstone, V.; Moloney, G.; O'Keeffe, G. W.; Taylor, R. S.; Kenny, L. C.; McCarthy, F. P.; McCowan, L. M. E.; Thompson, J. M. D.; Murray, D. M.
Abstract: Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.
Subjects: MOTHERS; CYTOKINES; BIOCHEMISTRY; INTERLEUKINS; PHENOMENOLOGICAL biology; COMMUNICATIVE disorders; BEHAVIOR disorders in children; T-test (Statistics); COMPARATIVE studies; AUTISM in children; DESCRIPTIVE statistics
Publication: Journal of Autism & Developmental Disorders, 2022, Vol 52, Issue 9, p3919
ISSN: 0162-3257
Publication type: Academic Journal
DOI: 10.1007/s10803-021-05271-7

Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder.

Casey, S.; Carter, M.; Looney, A. M.; Livingstone, V.; Moloney, G.; O'Keeffe, G. W.; Taylor, R. S.; Kenny, L. C.; McCarthy, F. P.; McCowan, L. M. E.; Thompson, J. M. D.; Murray, D. M.