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- Title
Behavioral correlates of maternal antibody status among children with autism.
- Authors
Braunschweig, Daniel; Duncanson, Paul; Boyce, Robert; Hansen, Robin; Ashwood, Paul; Pessah, Isaac N; Hertz-Picciotto, Irva; Van de Water, Judy
- Abstract
Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.
- Publication
Journal of autism and developmental disorders, 2012, Vol 42, Issue 7, p1435
- ISSN
1573-3432
- Publication type
Journal Article
- DOI
10.1007/s10803-011-1378-7