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- Title
Evaluation of a Records-Review Surveillance System Used to Determine the Prevalence of Autism Spectrum Disorders.
- Authors
Nonkin Avchen, Rachel; Wiggins, Lisa D.; Devine, Owen; Van Naarden Braun, Kim; Rice, Catherine; Hobson, Nancy C.; Schendel, Diana; Yeargin-Allsopp, Marshalyn
- Abstract
We conducted the first study that estimates the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of a population-based autism spectrum disorders (ASD) surveillance system developed at the Centers for Disease Control and Prevention. The system employs a records-review methodology that yields ASD classification (case versus non-ASD case) and was compared with classification based on clinical examination. The study enrolled 177 children. Estimated specificity (0.96, [CI = 0.94, 0.99]), PPV (0.79 [CI = 0.66, 0.93]), and NPV (0.91 [CI = 0.87, 0.96]) were high. Sensitivity was lower (0.60 [CI = 0.45, 0.75]). Given diagnostic heterogeneity, and the broad array of ASD in the population, identifying children with ASD is challenging. Records-based surveillance yields a population-based estimate of ASD that is likely conservative.
- Publication
Journal of Autism & Developmental Disorders, 2011, Vol 41, Issue 2, p227
- ISSN
0162-3257
- Publication type
Academic Journal
- DOI
10.1007/s10803-010-1050-7