We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome.
- Authors
Yuhas, Jennifer; Cordeiro, Lisa; Tassone, Flora; Ballinger, Elizabeth; Schneider, Andrea; Long, James M; Ornitz, Edward M; Hessl, David
- Abstract
Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
- Publication
Journal of autism and developmental disorders, 2011, Vol 41, Issue 2, p248
- ISSN
1573-3432
- Publication type
Journal Article
- DOI
10.1007/s10803-010-1040-9