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- Title
Cerebellum, language, and cognition in autism and specific language impairment.
- Authors
Hodge, Steven M; Makris, Nikos; Kennedy, David N; Caviness, Verne S, Jr; Howard, James; McGrath, Lauren; Steele, Shelly; Frazier, Jean A; Tager-Flusberg, Helen; Harris, Gordon J
- Abstract
We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6-13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I-V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.
- Publication
Journal of autism and developmental disorders, 2010, Vol 40, Issue 3, p300
- ISSN
1573-3432
- Publication type
Journal Article
- DOI
10.1007/s10803-009-0872-7