We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A double-blind, placebo-controlled trial of oral human immunoglobulin for gastrointestinal dysfunction in children with autistic disorder.
- Authors
Handen, Benjamin L; Melmed, Raun D; Hansen, Robin L; Aman, Michael G; Burnham, David L; Bruss, Jon B; McDougle, Christopher J
- Abstract
Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2-17 years) with autism and persistent GI symptoms. Endpoint analysis revealed no significant differences across treatment groups on a modified global improvement scale (validated in irritable bowel syndrome studies), number of daily bowel movements, days of constipation, or severity of problem behaviors. IGOH was well-tolerated; there were no serious adverse events. This study demonstrates the importance of conducting rigorous trials in children with autism and casts doubt on one GI mechanism presumed to exert etiological and/or symptomatic effects in this population.
- Publication
Journal of autism and developmental disorders, 2009, Vol 39, Issue 5, p796
- ISSN
1573-3432
- Publication type
Journal Article
- DOI
10.1007/s10803-008-0687-y