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- Title
Autism spectrum phenotype in males and females with fragile X full mutation and premutation.
- Authors
Clifford, Sally; Dissanayake, Cheryl; Bui, Quang M; Huggins, Richard; Taylor, Annette K; Loesch, Danuta Z
- Abstract
The behavioural phenotype of autism was assessed in individuals with full mutation and premutation fragile X syndrome (FXS) using the Autism Diagnostic Observation Scale-Generic (ADOS-G) and the Autism Diagnostic Interview (ADI-R). The participants, aged 5-80 years, comprised 33 males and 31 females with full mutation, 7 males and 43 females with premutation, and 38 non-fragile X relatives (29 males, 9 females). In the full mutation group, a total of 67% males and 23% females met either the Autism Disorder (AD) or the Autism Spectrum Disorder (ASD) criteria on at least one of the diagnostic tests. In the premutation group, 14% males and 5% females met the ADOS-G criteria for ASD. The presence of autism manifestations in males and females with full mutation and premutation provide support for a spectrum view.
- Publication
Journal of autism and developmental disorders, 2007, Vol 37, Issue 4, p738
- ISSN
0162-3257
- Publication type
Journal Article
- DOI
10.1007/s10803-006-0205-z