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- Title
A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).
- Authors
Richter, Suzanne; Bedard, Philippe L; Chen, Eric Xueyu; Clarke, Blaise A; Tran, Ben; Hotte, Sebastien J; Stathis, Anastasios; Hirte, Hal W; Razak, Albiruni R A; Reedijk, Michael; Chen, Zhuo; Cohen, Brenda; Zhang, Wen-Jiang; Wang, Lisa; Ivy, S Percy; Moore, Malcolm J; Oza, Amit M; Siu, Lillian L; McWhirter, Elaine
- Abstract
To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with gemcitabine; secondary objectives include the evaluation of safety, tolerability, pharmacokinetics, biomarkers of Notch signaling and preliminary anti-tumor activity.
- Publication
Investigational new drugs, 2014, Vol 32, Issue 2, p243
- ISSN
1573-0646
- Publication type
Journal Article
- DOI
10.1007/s10637-013-9965-4