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- Title
Unexpected renal toxicity associated with SGX523, a small molecule inhibitor of MET.
- Authors
Infante, Jeffrey R; Rugg, Terence; Gordon, Michael; Rooney, Isabelle; Rosen, Lee; Zeh, Karin; Liu, Raymond; Burris, Howard A; Ramanathan, Ramesh K
- Abstract
SGX523 is an orally bio-available, ATP competitive, small molecule inhibitor of MET, binding the kinase domain active site in a novel mode. Two phase 1, open-label, dose-escalation studies of SGX523 were conducted to evaluate both interrupted and continuous dosing schedules.
- Publication
Investigational new drugs, 2013, Vol 31, Issue 2, p363
- ISSN
1573-0646
- Publication type
Journal Article
- DOI
10.1007/s10637-012-9823-9