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- Title
Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies.
- Authors
Weiss, Glen J; Hidalgo, Manuel; Borad, Mitesh J; Laheru, Daniel; Tibes, Raoul; Ramanathan, Ramesh K; Blaydorn, Lisa; Jameson, Gayle; Jimeno, Antonio; Isaacs, Jeffrey D; Scaburri, Angela; Pacciarini, Maria Adele; Fiorentini, Francesco; Ciomei, Marina; Von Hoff, Daniel D
- Abstract
This phase I trial assessed the safety, maximally tolerated dose (MTD) and pharmacokinetics of TRKA/CDK inhibitor PHA-848125AC in adult patients with advanced/metastatic solid tumors.
- Publication
Investigational new drugs, 2012, Vol 30, Issue 6, p2334
- ISSN
1573-0646
- Publication type
Journal Article
- DOI
10.1007/s10637-011-9774-6