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- Title
Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies.
- Authors
Argiris, Athanassios; Feinstein, Trevor M; Wang, Lin; Yang, Tianbing; Agrawal, Shruti; Appleman, Leonard J; Stoller, Ronald G; Grandis, Jennifer R; Egloff, Ann Marie
- Abstract
Combined inhibition of epidermal growth factor receptor (EGFR) and Src family kinases (SFK) may lead to improved therapeutic effects. We evaluated the combination of dasatinib, an inhibitor of SFK and other kinases, and cetuximab, an anti-EGFR monoclonal antibody.
- Publication
Investigational new drugs, 2012, Vol 30, Issue 4, p1575
- ISSN
1573-0646
- Publication type
Journal Article
- DOI
10.1007/s10637-011-9732-3