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- Title
A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate.
- Authors
Bruce, Justine Yang; Eickhoff, Jens; Pili, Roberto; Logan, Theodore; Carducci, Michael; Arnott, Jamie; Treston, Anthony; Wilding, George; Liu, Glenn
- Abstract
Current treatment for metastatic renal cell cancer with vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKI) have provided improved overall survival, but complete responses are rare. We conducted a multicenter phase II study to evaluate the objective response rate of 2-methoxyestradiol (2ME2 NCD) alone and in combination with sunitinib for patients with metastatic renal cell carcinoma who have progressed on sunitinib alone.
- Publication
Investigational new drugs, 2012, Vol 30, Issue 2, p794
- ISSN
1573-0646
- Publication type
Journal Article
- DOI
10.1007/s10637-010-9618-9