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- Title
ATP-binding cassette sterol transporters are differentially expressed in normal and diseased human gallbladder.
- Authors
Yoon, Jai Hoon; Choi, Ho Soon; Jun, Dae Won; Yoo, Kyo-Sang; Lee, Jin; Yang, Sun Young; Kuver, Rahul
- Abstract
Gallbladder epithelial cells (GBEC) are exposed to high cholesterol concentrations in bile, and export cholesterol via an ATP-binding cassette (ABC) transporter-mediated pathway in vitro. These findings suggest that aberrant expression and/or function of ABC sterol transporters may be associated with cholesterol-related gallbladder diseases (CAGD). In this study, we investigated the relative levels of the sterol transporters ABCA1, ABCG5, and ABCG8 in human gallbladders in CAGD, and the relationship between ABCA1 and inflammation.
- Publication
Digestive diseases and sciences, 2013, Vol 58, Issue 2, p431
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-012-2481-0