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- Title
Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility.
- Authors
Jakab, Robert L; Collaco, Anne M; Ameen, Nadia A
- Abstract
Lubiprostone is a chloride channel activator in clinical use for the treatment of chronic constipation, but the mechanisms of action of the drug are poorly understood. The aim of this study was to determine whether lubiprostone exerts secretory effects in the intestine by membrane trafficking of ion transporters and associated machinery.
- Publication
Digestive diseases and sciences, 2012, Vol 57, Issue 11, p2826
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-012-2352-8