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- Title
Ca²⁺/calmodulin-dependent protein kinase II mediates platelet-derived growth factor-induced human hepatic stellate cell proliferation.
- Authors
Ping, An; Yihao, Tian; Jingxing, Dai; Minkai, Chen; Hesheng, Luo
- Abstract
Proliferation and activation of myofibroblastic hepatic stellate cells (HSCs) in response to growth factors is essential for the development of liver fibrosis. As one of the most potent factors, platelet-derived growth factor (PDGF) activates intracellular signals and contributes to sustained HSCs activation. Growing evidence has suggested that the Ca(2+) signal is involved in PDGF pathways. We showed previously for the first time that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is essential for human HSC proliferation. The inhibition of CaMKII by its specific inhibitor, KN-93, significantly decreased the HSC growth and increased expression of cell cycle suppressive regulators P53 and P21.
- Publication
Digestive diseases and sciences, 2012, Vol 57, Issue 4, p935
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-011-2014-2