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- Title
Ultra-rapid virological response, young age, low γ-GT/ALT-ratio, and absence of steatosis identify a subgroup of HCV Genotype 3 patients who achieve SVR with IFN-α(2a) monotherapy.
- Authors
Amanzada, Ahmad; Goralczyk, Armin; Moriconi, Federico; Blaschke, Martina; Schaefer, Inga-Marie; van Thiel, David; Mihm, Sabine; Ramadori, Giuliano
- Abstract
The standard treatment regimen for chronic HCV genotype 3 (HCV-G3) hepatitis consists of PEGylated interferon-α (IFN-α) and ribavirin at varying doses ranging from 400 to 1,200 mg and results in response rates of 80%. However, this therapy has substantial side-effects including anemia, is teratogenic, and costly. To reduce the side-effects of therapy, the role of monotherapy consisting of only IFN-α was investigated.
- Publication
Digestive diseases and sciences, 2011, Vol 56, Issue 11, p3296
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-011-1933-2