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- Title
Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells.
- Authors
Chung, Cho-Yun; Park, Young-Lan; Song, Young-A; Myung, Eun; Kim, Kyu-Yeol; Lee, Gi-Hoon; Ki, Ho-Seok; Park, Kang-Jin; Cho, Sung-Bum; Lee, Wan-Sik; Jung, Young-Do; Kim, Kyung-Keun; Joo, Young-Eun
- Abstract
Altered Recepteur d'Origine nantais (RON) expression transduces signals inducting invasive growth phenotype that includes cell proliferation, migration, matrix invasion, and protection of apoptosis in human cancer cells. The aims of the current study were to evaluate whether RON affects tumor cell behavior and cellular signaling pathways including activator protein-1 (AP-1) and Akt/forkhead box O (FoxO) in human colorectal cancer cells.
- Publication
Digestive diseases and sciences, 2012, Vol 57, Issue 2, p371
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-011-1892-7