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- Title
Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn's disease: a randomized placebo-controlled trial.
- Authors
Smith, Jill P; Bingaman, Sandra I; Ruggiero, Francesca; Mauger, David T; Mukherjee, Aparna; McGovern, Christopher O; Zagon, Ian S
- Abstract
Endogenous opioid peptides have been shown to play a role in the development and/or perpetuation of inflammation. We hypothesize that the endogenous opioid system is involved in inflammatory bowel disease, and antagonism of the opioid-opioid receptor will lead to reversal of inflammation.
- Publication
Digestive diseases and sciences, 2011, Vol 56, Issue 7, p2088
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-011-1653-7